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Test Code BEREP Ber-EP4 (Epithelial Cell Adhesion Molecule/EPCAM) Immunostain, Technical Component Only


Shipping Instructions


Attach the green pathology address label and the pink Immunostain Technical Only label included in the kit to the outside of the transport container.



Specimen Required


Supplies: Immunostain Technical Only Envelope (T693)

Specimen Type: Tissue

Container/Tube: Immunostain Technical Only Envelope (T693)

Preferred: 2 unstained positively charged glass slide (25- x 75- x 1-mm) per test ordered; sections 4-microns thick.

Acceptable: Formalin-fixed, paraffin-embedded (FFPE) tissue block

Additional Information:

1. Information on accessing digital images of IHC stains and the manual requisition form can be accessed through this website: www.mayomedicallaboratories.com/test-info/ihc/index.html

2. Clients ordering stains using a manual requisition form will not have access to digital images.

3. Clients wishing to access digital images must place the order for IHC stains electronically. Information regarding digital imaging can be accessed through this website: www.mayomedicallaboratories.com/test-info/ihc/faq.html


Forms

If not ordering electronically, complete, print, and send an Immunohistochemical (IHC)/In Situ Hybridization (ISH) Stains Request Form (T763) (http://www.mayomedicallaboratories.com/it-mmfiles/ihc-and-ish-stain-request-form-mc0767-09a.pdf).

Secondary ID

70364

Useful For

Aids in distinguishing basal cell carcinoma from squamous cell carcinoma of the skin

 

Aids in distinguishing pulmonary adenocarcinoma from mesothelioma

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
IHTOI IHC Initial, Tech Only No No
IHTOA IHC Additional, Tech Only No No

Method Name

Immunohistochemistry

Reporting Name

Ber-EP4 IHC, Tech Only

Specimen Type

TECHONLY

Specimen Stability Information

Specimen Type Temperature Time
TECHONLY Ambient (preferred)
  Refrigerated 

Reject Due To

Hemolysis

NA

Lipemia

NA

Icterus

NA

Other

Wet/frozen tissue

Cytology smears

Nonformalin fixed tissue

Nonparaffin embedded tissue

Noncharged slides

ProbeOn slides

 

Clinical Information

Epithelial cell adhesion molecule/EPCAM (Ber-EP4) is expressed on most epithelial cells of the body, with the exception of squamous epithelium and mesothelium. It has been used to distinguish basal cell carcinoma from squamous cell carcinoma of the skin, and to distinguish pulmonary adenocarcinoma from mesothelioma.

Interpretation

This test includes only technical performance of the stain (no pathologist interpretation is performed). If diagnostic consultation by a pathologist is required order PATHC / Pathology Consultation.

 

The positive and negative controls are verified as showing appropriate immunoreactivity. If a control tissue is not included on the slide, a scanned image of the relevant quality control tissue is available upon request. Contact 855-516-8404.

 

Interpretation of this test should be performed in the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.

Clinical Reference

1. Beer TW, Shepherd P, Theaker JM: Ber EP4 and Epithelial Membrane Antigen Aid Distinction of Basal Cell, Squamous Cell and Basosquamous Carcinomas of the Skin. Histopathology 2000;37:218-223

2. Ordonez NG: The Diagnostic Utility of Immunohistochemistry in Distinguishing Between Epithelioid Mesotheliomas and Squamous Carcinomas of the Lung: A Comparative Study. Modern Pathology 2006;19(3):417-428

3. Sheibani K, Shin SS, Kezirian J, et al: Ber-EP4 Antibody as a Discriminant in the Differential Diagnosis of Malignant Mesothelioma Versus Adenocarcinoma. American Journal of Surgical Pathology 1991;15(8):779-784

Day(s) and Time(s) Performed

Monday through Friday

Analytic Time

1 day

Performing Laboratory

Mayo Medical Laboratories in Rochester

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

88342-TC, primary

88341-TC, if additional IHC

LOINC Code Information

Test ID Test Order Name Order LOINC Value
BEREP Ber-EP4 IHC, Tech Only In Process

 

Result ID Test Result Name Result LOINC Value
70677 Ber-EP4 IHC, Tech Only No LOINC Needed