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Test Code HPSA Helicobacter pylori Antigen, Feces

Reporting Name

Helicobacter pylori Ag, F

Useful For

As an aid in the diagnosis of Helicobacter pylori

 

Monitoring the eradication of Helicobacter pylori after therapy (in most situations, confirmation of eradication is not mandatory)

Testing Algorithm

See Helicobacter pylori Diagnostic Algorithm in Special Instructions.

Performing Laboratory

Mayo Medical Laboratories in Rochester

Specimen Type

Fecal


Specimen Required


Supplies: Stool Collection Kit, Random (T635)

Submission Container/Tube: Plastic container

Specimen Volume: 5 g

Collection Instructions: Mix stool well.

Additional Information: Falsely negative results may be obtained within 2 weeks of treatment with antimicrobials, bismuth, or proton pump inhibitors – see cautions for details.


Specimen Minimum Volume

5 g

Specimen Stability Information

Specimen Type Temperature Time
Fecal Frozen (preferred) 60 days
  Refrigerated  48 hours

Reference Values

Negative

Day(s) and Time(s) Performed

Monday through Saturday; Varies

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

87338

LOINC Code Information

Test ID Test Order Name Order LOINC Value
HPSA Helicobacter pylori Ag, F 17780-8

 

Result ID Test Result Name Result LOINC Value
24088 Helicobacter pylori Ag, F 17780-8

Clinical Information

Helicobacter pylori is well recognized as the cause of chronic active gastritis, duodenal ulcer, and nonulcer dyspepsia.

 

Currently accepted methods for the diagnosis of Helicobacter pylori infection include, the urea breath test (UBT), and culture or histologic examination or direct urease testing (CLO test) of biopsy specimens obtained at the time of gastroduodenoscopy (ENDO). Each of these tests has its drawbacks, including lack of specificity (serology) or high cost, complexity, and inconvenience for the patient (UBT and ENDO).

 

The utility of this test in asymptomatic individuals is not known, but testing for Helicobacter pylori in such individuals is not generally recommended.

 

See Helicobacter pylori Diagnostic Algorithm in Special Instructions.

Interpretation

Positive results indicate the presence of Helicobacter pylori antigen in the stool.

 

Negative results indicate the absence of detectable antigen but does not eliminate the possibility of infection due to Helicobacter pylori.

Clinical Reference

1. NIH Consensus Development Panel. Helicobacter pylori in peptic ulcer disease. JAMA 1994;272:65-69

2. Report of the Digestive Health Initiative. International Update Conference on H. pylori. Tysons Corner, McLean, VA, Feb 13-16, 1997

Analytic Time

Same day/1 day

Reject Due To

Hemolysis

NA

Lipemia

NA

Icterus

NA

Other

Very mucoid stool; or a watery, diarrheal specimen; stool in transport media, swab, or preservative

Method Name

Enzyme-Linked Immunosorbent Assay (ELISA)