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Test Code ROM Measles (Rubeola) Antibodies, IgM, Serum

Reporting Name

Measles (Rubeola) Ab, IgM, S

Useful For

Determining acute-phase infection with rubeola (measles) virus

 

As an aid in identifying nonimmune individuals

Performing Laboratory

Mayo Medical Laboratories in Rochester

Specimen Type

Serum


Specimen Required


Container/Tube: 

Preferred: Serum gel

Acceptable: Red top

Specimen Volume: 0.5 mL


Specimen Minimum Volume

0.2 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 14 days
  Frozen  14 days

Reference Values

Negative (reported as negative or positive)

Day(s) and Time(s) Performed

Monday through Saturday; 9 a.m.

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

86765

LOINC Code Information

Test ID Test Order Name Order LOINC Value
ROM Measles (Rubeola) Ab, IgM, S 21503-8

 

Result ID Test Result Name Result LOINC Value
80979 Measles (Rubeola) Ab, IgM, S 21503-8

Clinical Information

Measles (rubeola) virus is a member of the family paramyxoviridae, which also includes mumps, respiratory syncytial virus, and parainfluenza viruses. Clinical infection with measles virus is characterized by a prodromal phase of high fever, cough, coryza, conjunctivitis, malaise, and Koplik's spots on the buccal mucosa. An erythematous rash then develops behind the ears and over the forehead, spreading to the trunk.

 

Measles virus is highly contagious; pregnant women, immuno-compromised, and nutritionally deficient individuals are at particularly high risk for serious complications of pneumonia and central nervous system involvement.(1-3)

 

Since intensive immunization began in the United States more than 2 decades ago, the incidence of measles infection has been reduced from approximately 1/2 million cases annually in the 1960s to fewer than 500 cases in recent years. Atypical measles can occur in patients who received killed measles virus vaccine and subsequently have been infected with the wild type strain of the virus.(4) In addition, many individuals remain susceptible to measles virus because of vaccine failure or nonimmunization. Screening for antibody to measles virus will aid in identifying these nonimmune individuals.

Interpretation

Positive IgM results, with or without positive IgG results, indicate a recent infection with measles virus.

 

Positive IgG results coupled with a negative IgM result indicate previous exposure to measles virus and immunity to this viral infection.

 

Negative IgG and IgM results indicate the absence of prior exposure to rubeola and nonimmunity.

 

Equivocal results should be followed up with a new serum specimen within 10 to 14 days.

Clinical Reference

1. Liebert UG: Measles virus infections of the central nervous system. Intervirology 1997;40:176-184

2. Norrby E, Kristensson K: Measles virus in the brain. Brain Res Bull 1997;44:213-220

3. Sable CA, Hayden FG: Orthomyxoviral and paramyxoviral infections in transplant patients. Infect Dis Clin North Am 1995;9:987-1003

4. Matsuzono Y, Narita M, Satake A, et al: Measles encephalomyelitis in a patient with a history of vaccination. Acta Paediatr Jpn 1995;37:374-376

5. Cremer, NE, Devlin VL, Riggs JL, Hagens SJ: 1984. Anomalous antibody responses in viral infection: specific stimulation or polyclonal activation? J Clin Microbio 1984;20:468-472

6. Gershon AA, Krugman S: Measles virus. In Diagnostic Procedures for Viral, Rickettsial and Chlamydial Infections. Fifth edition. Edited by EH Lennette, NJ Schmidt. Washington, DC, American Public Health Association, Inc., 1979;665-693

Analytic Time

Same day/1 day

Reject Due To

Hemolysis

Mild OK; Gross reject

Lipemia

Mild OK; Gross reject

Icterus

NA

Other

Heat-inactivated specimen

Method Name

Immunofluorescence Assay (IFA)