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Test Code VIPI Vasoactive Intestine Polypeptide (VIP), Immunostain Without Interpretation


Shipping Instructions


Attach the green pathology address label and the pink Immunostain Technical Only label included in the kit to the outside of the transport container.



Specimen Required


Supplies: Immunostain Technical Only Envelope (T693)

Specimen Type: Tissue

Container/Tube: Immunostain Technical Only Envelope (T693)

Preferred: 2 unstained positively charged glass slide (25 x 75 x 1 mm) per test ordered; sections 4-microns thick.

Acceptable: Formalin-fixed, paraffin-embedded (FFPE) tissue block

Additional Information:

1. Information on accessing digital images of IHC stains and the manual requisition form can be accessed through this website: www.mayomedicallaboratories.com/test-info/ihc/index.html

2. Clients ordering stains using a manual requisition form will not have access to digital images.

3. Clients wishing to access digital images must place the order for IHC stains electronically. Information regarding digital imaging can be accessed through this website: www.mayomedicallaboratories.com/test-info/ihc/faq.html


Secondary ID

70580

Useful For

Aids in the identification of islet cell tumors

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
IHTOA IHC Additional, Tech Only No No
IHTOI IHC Initial, Tech Only No No

Method Name

Immunohistochemistry

Reporting Name

VIP IHC, Tech Only

Specimen Type

TECHONLY

Specimen Stability Information

Specimen Type Temperature Time
TECHONLY Ambient (preferred)
  Refrigerated 

Reject Due To

Hemolysis

NA

Lipemia

NA

Icterus

NA

Other

Wet/frozen tissue
Cytology smears
Nonformalin fixed tissue
Nonparaffin embedded tissue
Noncharged slides
ProbeOn slides

Clinical Information

Excessive vasoactive intestine polypeptide (VIP) production by islet cell tumors has been associated with Verner-Morrison syndrome, also known as pancreatic cholera, in which patients have massive, watery diarrhea. A subset of normal cells in the pancreatic islets express VIP (<1%). Peripheral nerves and ganglion cells also serve as a positive internal control.

Interpretation

This test includes only technical performance of the stain (no pathologist interpretation is performed). If diagnostic consultation by a pathologist is required order PATHC / Pathology Consultation.

 

The positive and negative controls are verified as showing appropriate immunoreactivity.  If a control tissue is not included on the slide, a scanned image of the relevant quality control tissue is available upon request. Please contact 855-516-8404.

 

Interpretation of this test should be performed in the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.

Clinical Reference

1. Edvinsson L, Ekman, R: Distribution and dilatory effect of vasoactive intestinal polypeptide (VIP) in human cerebral Aateries. Peptides 1984;5(2):329-331

2. Smet PJ, Moore KH, Jonavicius J: Distribution and colocalization of calcitonin gene-related peptide, tachykinins, and vasoactive intestinal peptide in normal and idiopathic unstable human urinary bladder. Lab Invest 1997;77(1):37-49

3. Vaalasti A, Tainio H, Rechardt L: Vasoactive intestinal polypeptide (VIP)- like immunoreactivity in the nerves of human axillary sweat glands. J Invest Dermatol 1985;85:246-248

Day(s) and Time(s) Performed

Monday through Friday

Analytic Time

1 day

Performing Laboratory

Mayo Medical Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

88342-TC, primary

88341-TC, if additional IHC

LOINC Code Information

Result ID Test Result Name Result LOINC Value
70892 VIP IHC, Tech Only No LOINC Needed