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Test Code HPSA Helicobacter pylori Antigen, Feces

Reporting Name

Helicobacter pylori Ag, F

Useful For

Aiding in the diagnosis of Helicobacter pylori infection


Monitoring the eradication of Helicobacter pylori after therapy (in most situations, confirmation of eradication is not mandatory)

Testing Algorithm

See Helicobacter pylori Diagnostic Algorithm in Special Instructions.

Performing Laboratory

Mayo Medical Laboratories in Rochester

Specimen Type


Specimen Required

Supplies: Stool Collection Kit, Random (T635)

Submission Container/Tube: Plastic container

Specimen Volume: 5 g

Collection Instructions: Mix stool well.

Additional Information: Falsely negative results may be obtained within 2 weeks of treatment with antimicrobials, bismuth, or proton pump inhibitors-see cautions for details.

Specimen Minimum Volume

See Specimen Required

Specimen Stability Information

Specimen Type Temperature Time
Fecal Frozen (preferred) 60 days
  Refrigerated  48 hours

Reference Values


Day(s) and Time(s) Performed

Monday through Saturday; Varies

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
HPSA Helicobacter pylori Ag, F 17780-8


Result ID Test Result Name Result LOINC Value
24088 Helicobacter pylori Ag, F 17780-8

Clinical Information

Helicobacter pylori is well recognized as the cause of chronic active gastritis, duodenal ulcer, and nonulcer dyspepsia.


Currently accepted methods for the diagnosis of Helicobacter pylori infection include the urea breath test (UBT / Helicobacter pylori Breath Test) and culture or histologic examination or direct urease testing of biopsy specimens obtained at the time of gastroduodenoscopy. Each of these tests has its drawbacks, including lack of specificity (serology) or high cost, complexity, and inconvenience for the patient.


The utility of this test in asymptomatic individuals is not known, but testing for Helicobacter pylori in such individuals is not generally recommended.


See Helicobacter pylori Diagnostic Algorithm in Special Instructions.


Positive results indicate the presence of Helicobacter pylori antigen in the stool.


Negative results indicate the absence of detectable antigen, but does not eliminate the possibility of infection due to Helicobacter pylori.

Clinical Reference

Moayyedi PM, Lacy BE, Andrews CN, et al: ACG and CAG Clinical Guideline: Management of

Dyspepsia. Am J Gastroenterol 2017;112(7):988-1013

Analytic Time

Same day/1 day

Reject Due To








Very mucoid stool; or a watery, diarrheal specimen; stool in transport media, swab, or preservative

Method Name

Enzyme-Linked Immunosorbent Assay (ELISA)