Sign in →

Test Code LACTO Lactotransferrin IHC, Technical Component Only

Advisory Information

This test includes only technical performance of the stain (no pathologist interpretation is performed). If diagnostic consultation by a pathologist is required order PATHC / Pathology Consultation.

Shipping Instructions

Attach the green pathology address label and the pink Immunostain Technical Only label included in the kit to the outside of the transport container.

Specimen Required

Supplies: Immunostain Technical Only Envelope (T693)

Specimen Type: Tissue

Container/Tube: Immunostain Technical Only Envelope (T693)

Preferred: 2 unstained positively charged glass slide (25- x 75- x 1-mm) per test ordered; sections 4-microns thick.

Acceptable: Formalin-fixed, paraffin-embedded (FFPE) tissue block

Secondary ID


Useful For

Identifying the presence of lactotransferrin in amyloid deposits


An adjunct to amyloid subtyping analysis by mass spectrometry

Disease States

  • Amyloidosis

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
IHTOI IHC Initial, Tech Only No No
IHTOA IHC Additional, Tech Only No No

Reporting Name

Lactotransferrin IHC, Tech Only

Specimen Type


Specimen Stability Information

Specimen Type Temperature Time
TECHONLY Ambient (preferred)

Reject Due To








Wet/frozen tissue
Cytology smears
Nonformalin fixed tissue
Nonparaffin embedded tissue
Noncharged slides
ProbeOn slides

Clinical Information

Lactotransferrin (also referred to as lactoferrin) is a secreted iron-binding glycoprotein found in milk, tears, and leukocytes. It has been shown to be expressed in various tissues including tonsil, intestinal epithelium, kidney, and various regions of the brain where it is thought to play a role in iron metabolism and defense against bacteria. Lactotransferrin also plays a role in amyloidosis, specifically of the cornea, but has been observed in other tissue types.


This test includes only technical performance of the stain (no pathologist interpretation is performed). Mayo Clinic cannot provide an interpretation of tech only stains outside the context of a pathology consultation. If an interpretation is needed, refer to test code PATHC / Pathology Consultation for a full diagnostic evaluation or second opinion of the case. All material associated with the case is required. Additional specific stains may be requested as part of the pathology consultation, and will be performed as necessary at the discretion of the Mayo pathologist.


The positive and negative controls are verified as showing appropriate immunoreactivity and documentation is retained at Mayo Clinic Rochester. If a control tissue is not included on the slide, a scanned image of the relevant quality control tissue is available upon request. Contact 855-516-8404.


Interpretation of this test should be performed in the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.

Clinical Reference

1. Ando Y, Nakamura M, Kai H, et al: A novel localized amyloidosis associated with lactoferrin in the cornea. Lab Invest 2002;82(6):757-765

2. Furuya S, Masurmori N, Furuya R, et al: Characterization of localized seminal vesicle amyloidosis causing hemospermia: An analysis using immunohistochemistry and magnetic resonance imaging. J Urol 2005;173:1273-1277

3. Kebbel A, Rocken C: Immunohistochemical classification of amyloid in surgical pathology revisited. Am J Surg Pathol 2006;30(6):673-683

4. Tuccari G, Barresi G: Lactoferrin in human tumours: immunohistochemical investigations during more than 25 years. Biometals 2011;24:775-784

Day(s) and Time(s) Performed

Monday through Friday

Analytic Time

1 day

Performing Laboratory

Mayo Medical Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

88342-TC, primary

88341-TC, if additional IHC

LOINC Code Information

Result ID Test Result Name Result LOINC Value
70896 Lactotransferrin IHC, Tech Only No LOINC Needed