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Test Code PBRC Lead/Creatinine Ratio, Urine


Specimen Required


Only orderable as part of a profile. See PBRCR / Lead/Creatinine Ratio, Random, Urine or HMCRU / Heavy Metal/Creatinine Ratio, with Reflex, Urine.


Secondary ID

48548

Useful For

Detecting clinically significant lead exposure in random urine specimens

Method Name

Only orderable as part of profile. See PBRCR / Lead/Creatinine Ratio, Random, Urine or HMCRU / Heavy Metal/Creatinine Ratio, with Reflex, Urine.

 

Inductively Coupled Plasma-Mass Spectrometry (ICP-MS)

Reporting Name

Lead/Creatinine Ratio, U

Specimen Type

Urine

Specimen Minimum Volume

3 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Refrigerated (preferred) 28 days
  Ambient  28 days
  Frozen  28 days

Reject Due To

All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.

Clinical Information

Increased urine lead concentration per gram of creatinine indicates significant lead exposure. Measurement of urine lead concentration per gram of creatinine before and after chelation therapy have been used as an indicator of significant lead exposure. An increase in lead concentration per gram of creatinine in the postchelation specimen of up to 6 times the concentration in the prechelation specimen is normal.

 

Blood lead is the best clinical correlate of toxicity.

 

For additional information, see PBBD / Lead with Demographics, Blood.

Reference Values

Only orderable as part of a profile. See PBRCR / Lead/Creatinine Ratio, Random, Urine or HMCRU / Heavy Metal/Creatinine Ratio, with Reflex, Urine.

Interpretation

Urinary excretion of less than 4 mcg/g creatinine is not associated with any significant lead exposure.

 

Urinary excretion greater than 4 mcg/g creatinine is usually associated with pallor, anemia, and other evidence of lead toxicity.

Clinical Reference

1. Kosnett MJ, Wedeen RP, Rotherberg SJ, et al: Recommendations for medical management of adult lead exposure. Environ Health Perspect 2007;115:463-471

2. De Burbane C, Buchet JP, Leroyer A, et al: Renal and neurologic effects of cadmium, lead, mercury, and arsenic in children: evidence of early effects and multiple interactions at environmental exposure levels. Environ Health Perspect 2006;114:584-590

Day(s) and Time(s) Performed

Monday through Friday; 7 p.m.

Analytic Time

1 day

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

LOINC Code Information

Test ID Test Order Name Order LOINC Value
PBRC Lead/Creatinine Ratio, U 13466-8

 

Result ID Test Result Name Result LOINC Value
48548 Lead/Creatinine Ratio, U 13466-8