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Test Code SDEX Hemoglobin S, Screen, Blood

Reporting Name

Hemoglobin S, Scrn, B

Useful For

Screening for presence or absence of hemoglobin S (sickle cell disease)

Note: for quantification of hemoglobin S order HBELC / Hemoglobin Electrophoresis Cascade, Blood

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Whole Blood EDTA

Necessary Information

1. Patient's age is required.

2. Include recent transfusion information.

Specimen Required


Preferred: Lavender top (EDTA)

Acceptable: ACD (solution B), heparin

Specimen Volume: 1 mL

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Whole Blood EDTA Refrigerated 7 days

Reference Values


Day(s) and Time(s) Performed

Monday through Saturday

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
SDEX Hemoglobin S, Scrn, B 4621-9


Result ID Test Result Name Result LOINC Value
9180 Hemoglobin S, Scrn, B 4621-9

Clinical Information

Homozygous hemoglobin S (sickle cell disease) is a serious chronic hemolytic anemia most commonly found in those of African or Middle Eastern descent.


Hemoglobin S is freely soluble when fully oxygenated; when oxygen is removed, polymerization of the abnormal hemoglobin occurs, forming tactoids that are rigid and deformed cells. This leads to sickling of the cells, hemolysis, and many other complications.


Heterozygous hemoglobin S (sickle cell trait) is the most common hemoglobinopathy in the United States. This condition is present in about 8% of African Americans. Usually, hemoglobin S trait exhibits no clinical or hematological effects. A small fraction of people with sickle cell trait have recurrent hematuria.


A positive result should be followed by a complete hemoglobin evaluation (HBELC / Hemoglobin Electrophoresis Cascade, Blood) to confirm the presence and concentration of hemoglobin S.

Clinical Reference

Fairbanks VF: Laboratory methods and case studies. In Hemoglobinopathies and Thalassemias. Edited by BC Decker, New York, Thieme-Stratton Inc, 1980, pp 105-107

Analytic Time

1 day

Reject Due To

Gross hemolysis Reject

Method Name

Hemoglobin S Solubility


If not ordering electronically, complete, print, and send a Benign Hematology Test Request Form (T755) with the specimen.