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Test Code UHSD Hemosiderin, Urine

Reporting Name

Hemosiderin, U

Useful For

Detecting hemosiderinuria, secondary to excess hemolysis, as in incompatible blood transfusions, severe acute hemolytic anemia, or hemochromatosis

Performing Laboratory

Mayo Medical Laboratories in Rochester

Specimen Type


Specimen Required

Collection Container/Tube: Clean, plastic urine collection container

Submission Container/Tube: Plastic, 60-mL urine bottle

Specimen Volume: 13 mL

Collection Instructions:

1. Collect a random urine specimen.

2. No preservative.

Specimen Minimum Volume

12 mL

Specimen Stability Information

Specimen Type Temperature Time
Urine Refrigerated (preferred)

Reference Values

Hemosiderin: negative (reported as positive or negative)

Hemoglobin (internal specimens only): negative

RBC (internal specimens only): 0-2 rbc/hpf

Day(s) and Time(s) Performed

Monday through Sunday; Continuously

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
UHSD Hemosiderin, U 17783-2


Result ID Test Result Name Result LOINC Value
US_HD Hemosiderin, U 17783-2
HGB7 Hemoglobin 725-2
RBC3 RBC 46419-8

Clinical Information

When the plasma hemoglobin level is >50 to 200 mg/dL after hemolysis, the capacity of haptoglobin to bind hemoglobin is exceeded, and hemoglobin readily passes through the glomeruli of the kidney. Part of the hemoglobin is absorbed by the proximal tubular cells where the hemoglobin iron is converted to hemosiderin. When these tubular cells are later shed into the urine, hemosiderinuria results. If all of the hemoglobin cannot be absorbed into the tubular cells, hemoglobinuria results.


Hemosiderin is found as yellow-brown granules that are free or in epithelial cells and occasionally in casts in an acidic or neutral urine.


A positive hemosiderin indicates excess red cell destruction.


Hemosiderinuria may still be detected after hemoglobin has cleared from the urine and hemoglobin dipstick is negative.

Clinical Reference

Henry JB: Clinical Diagnosis and Management by Laboratory Methods. 18th edition. Philadelphia, WB Saunders Company, 1991, pp 412-413

Analytic Time

1 day

Reject Due To










Method Name

Rous Method